Endocrine Abstracts

Calcium is important for physiological functioning in many tissues and is essential in mucus secretion and muscle contraction. Intracellular concentrations of calcium are regulated by calcium-related proteins such as TRPV4, TRPV6, CaBP-9k, NCX1, and PMCA1. In this study, the relationship between secretion of pulmonary mucus and calcium regulation was investigated. To confirm the effect of steroid hormones, immature mice were injected with estrogen (E2) or progesterone (P4) and...

Endocrine-disrupting chemicals (EDCs) are structures similar to steroids hormones which can interfere with hormone synthesis and normal physiological functions of male and female reproductive organs. EDCs tend to bind to steroid hormone receptors. Sex steroid hormones influence calcium signaling of the cardiac muscle in early embryo-development. Progesterone (P4) has been reported to affect both blood pressure and other aspects of the cardiovascular system. To confirm the affe...